Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9)

Kazuma Kiyotani, Hiroshi Yamazaki, Masaki Fujieda, +11

Pharmacogenetics

Promoter RegionCoumarin 7-Hydroxylase ActivitiesMedicineGeneticsHuman Polymorphism +13

Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3A7: lack of co-regulation of the expression of CYP3A in Japanese livers

Satoshi Yamaori, Hiroshi Yamazaki, Shunsuke Iwano, +6

Xenobiotica

CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects

Satoshi Yamaori, Hiroshi Yamazaki, Shunsuke Iwano, +6

Drug Metabolism and Pharmacokinetics

Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

Tomohisa Nakada, Kazuma Kiyotani, Shunsuke Iwano, +8

The Journal of Toxicological Sciences

Cell DeathTumor BiologyRespiratory ToxicologyNicotinePulmonary Pharmacology +14

Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins.

Kenji Toide, Hiroshi Yamazaki, Rikako Nagashima, +5

PubMed

White CellsToxicological MechanismOxidative StressCarbonyl MetabolismRespiratory Toxicology +21

A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons

Shunsuke Iwano, Manabu Nukaya, Tetsuya Saito, +2

Biochemical and Biophysical Research Communications

InflammationVascular DiseaseCardiovascular DiseaseBiochemistryMedicine +8

Two Novel CYP2D6*10 Haplotypes As Possible Causes of a Poor Metabolic Phenotype in Japanese

Masayuki Matsunaga, Hiroshi Yamazaki, Kazuma Kiyotani, +9

Drug Metabolism and Disposition

Adalimumab in Japanese patients with active ulcers of pyoderma gangrenosum: Twenty‐six‐week phase 3 open‐label study

Kenshi Yamasaki, Keiichi Yamanaka, Yiwei Zhao, +4

The Journal of Dermatology

RheumatologyPhase 3Lower Extremity WoundClinical TrialsPsoriatic Arthritis +9

CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons

Shunsuke Iwano, Fumie Asanuma, Manabu Nukaya, +2

Biochemical and Biophysical Research Communications

InflammationVascular DiseaseBiochemistryMedicineEndothelial Dysfunction +6

Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells

Ikuo Sugiyama, Norie Murayama, Ayaka Kuroki, +4

Xenobiotica