Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity

Jia Li, Feihai Shen, Cuiwen Guan, +6

PLoS ONE

InflammationBiochemistryMedicineLiver PhysiologyLipid Peroxidation +11

Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells

Yisen Cheng, Gaojian Chen, Li Wang, +5

Toxicology Letters

Mitochondrial FunctionBiochemistryMedicineLipid PeroxidationCell Death +7

Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes

Yanqin Yang, Wenwen Wang, Zhewen Xiong, +4

Toxicology in Vitro

MitophagyTriptolide-induced ToxicityMolecular PhysiologySignal TransductionBiochemistry +9

Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes

Yue Xi, Wenwen Wang, Li Wang, +4

Toxicology and Applied Pharmacology

Mitochondrial Membrane PermeabilizationCardiomyopathyMolecular PhysiologyMitochondrial FunctionMedicine +7

Inhibition of glycogen synthase kinase 3beta ameliorates triptolide-induced acute cardiac injury by desensitizing mitochondrial permeability transition

Wenwen Wang, Yanqin Yang, Zhewen Xiong, +4

Toxicology and Applied Pharmacology

CardiomyopathyHeart FailureMolecular PhysiologyGlycogen SynthaseMitochondrial Function +10

Triptolide induces mitochondria-mediated apoptosis of Burkitt's lymphoma cell via deacetylation of GSK-3β by increased SIRT3 expression

Jiamin Kong, Li Wang, Lü Ren, +4

Toxicology and Applied Pharmacology

Sirt3 ExpressionTumor BiologyLymphoid NeoplasiaMitochondria-mediated ApoptosisMedicine +8

Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes

Feihai Shen, Zhewen Xiong, Jiamin Kong, +4

Toxicology Letters

Thioredoxin SystemMolecular PhysiologySignal TransductionSignaling PathwayLiver Physiology +6

Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway

Ji Pan, Feihai Shen, Kang Tian, +4

Toxicology in Vitro

Redox SignalingSignal TransductionNrk-52e CellsBiochemistryGsk-3β/fyn Pathway +10

Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis

Yonghong Liang, Sixin Chen, Suqin Han, +3

Toxicology Letters

InflammationToosendanin Induced HepatotoxicityCell SignalingLiver PhysiologyHepcidin +9

Triptolide dysregulates glucose uptake via inhibition of IKKβ-NF-κB pathway by p53 activation in cardiomyocytes

Yue Xi, Yunhui Zhang, Ji Pan, +4

Toxicology Letters

Insulin SignalingMolecular PhysiologyIkkβ-nf-κb PathwayMedicineDiabetes +7