Qiufen Xue

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Matthew M. Weiss, Toni Williamson, Safura Babu‐Khan et al. · Journal of Medicinal Chemistry · 2012 · 63 citations · Full text

Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 12. Structure–Activity Relationships Associated with 4-Fluoro-6-azaindole Derivatives Leading to the Identification of 1-(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-3-yl)ethane-1,2-dione (BMS-585248)

Alicia Regueiro‐Ren, Qiufen Xue, Jacob J. Swidorski et al. · Journal of Medicinal Chemistry · 2013 · 50 citations

Vitro Potency, Good Potency, Azaindole Core +17

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Thomas A. Dineen, Matthew M. Weiss, Toni Williamson et al. · Journal of Medicinal Chemistry · 2012 · 41 citations · Full text

Pharmacotherapy, Chemical Biology, Pharmaceutical Chemistry +19

An efficient one-pot synthesis of 3-glyoxylic acids of electron-deficient substituted azaindoles by ionic liquid imidazolium chloroaluminate-promoted Friedel–Crafts acylation

Kap‐Sun Yeung, Zhilei Qiu, Michelle E. Farkas et al. · Tetrahedron Letters · 2008 · 28 citations

Chemical Engineering, 3-Glyoxylic Acids, Engineering +6

Hydroxyethylamine-based inhibitors of BACE1: P1–P3 macrocyclization can improve potency, selectivity, and cell activity

Lewis D. Pennington, Douglas A. Whittington, Michael D. Bartberger et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 18 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +12