David Hargreaves

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam et al. · Nature Communications · 2018 · 479 citations · Full text

Crystal Structure of DNA Recombination Protein RuvA and a Model for Its Binding to the Holliday Junction

John B. Rafferty, Svetlana E. Sedelnikova, David Hargreaves et al. · Science · 1996 · 167 citations

Crystal Structure, Biochemistry, Protein Assembly +13

Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 Å resolution

David Hargreaves, David W. Rice, Svetlana E. Sedelnikova et al. · Nature Structural Biology · 1998 · 136 citations

Crystal Structure, E.coli Ruva, Protein X-ray Crystallography +6

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

William McCoull, Tony Cheung, Erica Anderson et al. · ACS Chemical Biology · 2018 · 133 citations · Full text

Hematological Malignancy, Lymphoid Neoplasia, B-cell Lymphoma 6 +14

Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains

S. Gerhardt, G. Hassall, Paul Hawtin et al. · Journal of Molecular Biology · 2007 · 94 citations

Protein Function, Protein Assembly, Protein Folding +9