IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt, Kelly Kersten, Chris W. Doornebal, +8

Nature

Breast Cancer MetastasisCancer ImmunosurveillanceLymphocyte DevelopmentImmune RegulationImmunology +6

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

Max D. Wellenstein, Seth B. Coffelt, Danique E. M. Duits, +17

Nature

InflammationBreast Cancer MetastasisBreast OncologyMedicineImmunology +6

IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

Olga Blomberg, Lorenzo Spagnuolo, Hannah Garner, +26

Cancer Cell

Cancer ImmunosurveillanceAutoimmune DiseaseImmunologyImmune Checkpoint InhibitorAutoimmunity +7

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

Camilla Salvagno, Metamia Ciampricotti, Sander Tuit, +15

Nature Cell Biology

InflammationCytokineMedicineImmunologyTumor Immunity +9

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, +11

OncoImmunology

The identification and developmental requirements of colonic <scp>CD</scp>169⁺ macrophages

Ida H. Hiemstra, Marieke R. Beijer, Henrike Veninga, +6

Immunology

Neoadjuvant immune checkpoint blockade triggers persistent and systemic T _reg activation which blunts therapeutic efficacy against metastatic spread of breast tumors

Olga Blomberg, Kevin Kos, Lorenzo Spagnuolo, +13

OncoImmunology

Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche

Kevin Kos, Muhammad Assad Aslam, Rieneke van de Ven, +14

Cell Reports

Cancer ImmunosurveillanceMedicineT-regulatory CellImmunologyTumor Immunity +7

Excreted/secreted Trichuris suis products reduce barrier function and suppress inflammatory cytokine production of intestinal epithelial cells

Ida H. Hiemstra, Elsenoor J. Klaver, Kim Vrijland, +5

Molecular Immunology

InflammationMucosal ImmunologyMedicineImmunologyIntestinal Epithelial Cells +5

Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer

Chris W. Doornebal, Kim Vrijland, Cheei‐Sing Hau, +5

Pain