Dan Chen

The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion

Anna-Maria Globig, Steven Zhao, Jessica Roginsky et al. · Nature · 2023 · 194 citations · Full text

Autonomic System, Molecular Physiology, Sympathetic Nervous System +9

Manipulating mitochondrial electron flow enhances tumor immunogenicity

Kailash Chandra Mangalhara, Siva Karthik Varanasi, Melissa Johnson et al. · Science · 2023 · 105 citations · Full text

Radiation Oncology, Cancer Immunosurveillance, Mitochondrial Function +13

CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma

Dan Chen, Siva Karthik Varanasi, Toshiro Hara et al. · Immunity · 2023 · 98 citations · Full text

Neuro-oncology, Microglia Phagocytosis, Cancer Immunosurveillance +13

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

Siva Karthik Varanasi, Dan Chen, Yingluo Liu et al. · Science · 2025 · 95 citations · Full text

Nutrient-driven histone code determines exhausted CD8 ⁺ T cell fates

Shixin Ma, Michael S. Dahabieh, Thomas H. Mann et al. · Science · 2024 · 56 citations · Full text