mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression

Nahid Khan, Joni Nikkanen, Shuichi Yatsuga, +7

Cell Metabolism

Mitochondrial MyopathyMitophagyMitochondrial FunctionMitochondrial DynamicPhysiology +5

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Joni Nikkanen, Saara Forsström, Liliya Euro, +23

Cell Metabolism

Genome InstabilityMitochondrial BiogenesisMitochondrial FunctionNatural SciencesGenetics +4

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

Kirthana Ganeshan, Joni Nikkanen, Kevin Man, +7

Cell

Energy HomeostasisEnergy MetabolismSignal TransductionPhysiologyMetabolism +3

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

Saara Forsström, Christopher B. Jackson, Christopher J. Carroll, +17

Cell Metabolism

MechanobiologyMitochondrial MyopathyMitophagyFibrosisMitochondrial Function +8

An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice

Joni Nikkanen, Yew Ann Leong, William C. Krause, +8

Science

GeneticsInnate Immune SystemImmunologyImmune RegulationFatty Liver Disease +22

Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers

Jana Buzková, Joni Nikkanen, Sofia Ahola, +9

EMBO Molecular Medicine

Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes

Olesia Ignatenko, Satu Malinen, Sofiia Rybas, +5

The Journal of Cell Biology

Neurodegenerative DiseasesMitophagyDevelopmental BiologySystems BiologyMitochondrial Function +12

A maternal brain hormone that builds bone

Muriel Babey, William C. Krause, Kun Chen, +15

Nature

Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect

Olesia Ignatenko, Joni Nikkanen, Alexander Kononov, +3

Life Science Alliance

A complex genomic locus drives mt <scp>DNA</scp> replicase <scp>POLG</scp> expression to its disease‐related nervous system regions

Joni Nikkanen, Juan C. Landoni, Diego Balboa, +6

EMBO Molecular Medicine