First Asymmetric Total Synthesis of Tetrodotoxin

Norio Ohyabu, Toshio Nishikawa, Minoru Isobe

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringBiochemistryNatural SciencesDiversity-oriented Synthesis +11

Improved Conditions for Facile Overman Rearrangement¹

Toshio Nishikawa, Masanori Asai, Norio Ohyabu, +1

The Journal of Organic Chemistry

Order TheoryMolecular SciencesBioorganic ChemistryEngineeringBiochemistry +8

Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

Tomoaki Hasui, Nobuyuki Matsunaga, Taiichi Ora, +16

Journal of Medicinal Chemistry

Combinatorial ChemistryCrystal StructureMedicinal ChemistryBenzoxazin-3-one DerivativesScaffold Hopping +11

Stereocontrolled Synthesis of (−)-5,11-Dideoxytetrodotoxin

Toshio Nishikawa, Masanori Asai, Norio Ohyabu, +2

Angewandte Chemie International Edition

Derivative (Chemistry)DerivativesBioorganic ChemistryBiochemistryNatural Sciences +10

Synthesis of a common key intermediate for (−)-tetrodotoxin and its analogs

Toshio Nishikawa, Masanori Asai, Norio Ohyabu, +3

Tetrahedron

EngineeringOrganic ChemistryCommon Key IntermediatePharmacologySynthetic Chemistry +2

Stereocontrolled synthesis of (−)-5,11-dideoxytetrodotoxin

Masanori Asai, Toshio Nishikawa, Norio Ohyabu, +2

Tetrahedron

PharmacologyStereocontrolled SynthesisStereoselective Synthesis

Design, synthesis, and structure–activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists

Tomoaki Hasui, Taiichi Ohra, Norio Ohyabu, +12

Bioorganic & Medicinal Chemistry

DerivativesMedicineDihydropyrrol-2-one DerivativesPharmacological AgentOrganic Chemistry +6

Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist

Tatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, +18

ACS Medicinal Chemistry Letters

New synthetic route of guanidine from trichloroacetamide for tetrodotoxin and its related compounds

Toshio Nishikawa, Norio Ohyabu, Noboru Yamamoto, +1

Tetrahedron

BiochemistryMedicineNew Synthetic RouteOrganic ChemistryRelated Compounds +4

Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists

Tomoaki Hasui, Norio Ohyabu, Taiichi Ohra, +20

Bioorganic & Medicinal Chemistry

BiochemistryMedicineRational Drug DesignMechanism Of ActionPharmacological Agent +5