A multifunctional bispecific antibody protects against <i>Pseudomonas aeruginosa</i>

Antonio DiGiandomenico, Ashley Keller, Cuihua Gao, +16

Science Translational Medicine

Identification of broadly protective human antibodies to<i>Pseudomonas aeruginosa</i>exopolysaccharide Psl by phenotypic screening

Antonio DiGiandomenico, Paul Warrener, Melissa Hamilton, +16

The Journal of Experimental Medicine

Phenotypic ScreeningMicrobial PathogensImmunologyAntimicrobial ChemotherapyMab Discovery Strategy +18

A Novel Anti-PcrV Antibody Providing Enhanced Protection against Pseudomonas aeruginosa in Multiple Animal Infection Models

Paul Warrener, Reena Varkey, Jessica Bonnell, +8

Antimicrobial Agents and Chemotherapy

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae

Meghan E. Pennini, Anna De Marco, Mark Pelletier, +16

Nature Communications

Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28

Christoph Kahl, Jessica Bonnell, Suja Hiriyanna, +5

Vaccine

VaccinationVaccine DevelopmentImmunologyPotent Immune ResponsesVaccine Design +1

Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4

Taylor S. Cohen, Mark Pelletier, Lily Cheng, +12

JCI Insight

Microbial PathogensKlebsiella PneumoniaeImmunologyImmune RegulationInnate Immune System +17

Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice

Taylor S. Cohen, Virginia Takahashi, Jessica Bonnell, +11

Journal of Clinical Investigation

Microbial PathogensInnate Immune SystemImmunologyImmune RegulationPathology +25

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

Caroline Colley, Bojana Popovic, Sudharsan Sridharan, +19

mAbs

Crystal StructureImmunologyImmunodominanceImmunologic MechanismPotent Anaphylatoxin +15

Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA

Qun Wang, Yan Chen, Romana Cvitkovic, +9

PLoS ONE

Microbial PathogensKlebsiella PneumoniaeImmunologyPathologyImmunodominance +18

Complement C5a induces PD-L1 expression and acts in synergy with LPS through Erk1/2 and JNK signaling pathways

Ling–Ling An, Jacob V. Gorman, Geoffrey L. Stephens, +6

Scientific Reports