P. Hambleton

Dihydroorotate Dehydrogenase Is a High Affinity Binding Protein for A77 1726 and Mediator of a Range of Biological Effects of the Immunomodulatory Compound

Richard A. Williamson, Christopher Yea, P.A. Robson et al. · Journal of Biological Chemistry · 1995 · 196 citations · Full text

Synthesis, Structure−Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors:  2-Cyano-3-cyclopropyl-3-hydroxy- <i>N</i>-[3‘-methyl-4‘-(trifluoromethyl)phenyl]propenamide and Related Compounds

Elizabeth Kuo, P. Hambleton, David P. Kay et al. · Journal of Medicinal Chemistry · 1996 · 90 citations · Full text

Pharmaceutical Science, Pyrimidine Biosynthesis, Pharmacotherapy +19

Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide.

R. Williamson, Christopher Yea, P.A. Robson et al. · PubMed · 1996 · 41 citations

Dihydroorotate Dehydrogenase, Aldehyde Dehydrogenase, Biological Effects +6

Studies on carrageenin air pouch inflammation in the rat.

P. Hambleton, Peter Miller · PubMed · 1989 · 29 citations · Full text

Acute Lung Injury, Inflammation, Vascular Permeability +11

Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis

P. Hambleton, Stephen B. McMahon · Inflammation Research · 1990 · 27 citations

Adjuvant Arthritis, Immunology, Drug Allergy +17