Active transcription and essential role of RNA polymerase II at the centromere during mitosis

F. Lyn Chan, Owen J. Marshall, Richard Saffery, +4

Proceedings of the National Academy of Sciences

Rna Polymerase IiGeneticsCell CycleActive TranscriptionTranscriptional Regulation +21

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

Maheshi Udugama, Fiona Chang, F. Lyn Chan, +7

Nucleic Acids Research

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama, Elaine Sanij, Hsiao P. J. Voon, +12

Proceedings of the National Academy of Sciences

GeneticsEpigeneticsTumor BiologyRepetitive HeterochromatinCancer Cell Biology +15

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

Fiona Chang, James D. McGhie, F. Lyn Chan, +5

Nucleic Acids Research

Epigenetic ChangeGeneticsPml BodiesEpigeneticsTranscriptional Regulation +21

CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells

Fiona Chang, F. Lyn Chan, James D. McGhie, +5

Nucleic Acids Research

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

Maheshi Udugama, Linda Hii, Andrew Garvie, +8

Nature Communications

Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase

Maheshi Udugama, Benjamin Vinod, F. Lyn Chan, +10

Nucleic Acids Research

Histone ModificationsHistone H3.3 PhosphorylationEpigenetic ChangeGeneticsMolecular Biology +17

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

F. Lyn Chan, Benjamin Vinod, Karel Novy, +10

Nucleic Acids Research

Molecular RegulationGenomic MechanismMolecular BiologyCell CycleTerf1 Binding +15