A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

Daisuke Tanaka, Yusuke Tsuda, Takaaki Shiyama, +6

Journal of Medicinal Chemistry

Bioorganic ChemistryHit IdentificationLigand EfficiencyLead IdentificationChemical Biology +16

Preparation of novel pyranosyl fluorides of 3-deoxy-D- -2-octulosonic acid (KDO) feasible for synthesis of KDO α-glycosides

Masahiro Imoto, Naoto Kusunose, Y. Matsuura, +2

Tetrahedron Letters

EngineeringNovel Pyranosyl FluoridesKdo α-GlycosidesGlycobiologyOrganic Chemistry +4

Structural requirements of lipid A species in activation of clotting enzymes from the horseshoe crab, and the human complement cascade

Haruhiko Takada, Shozo Kotani, Shigenori Tanaka, +9

European Journal of Biochemistry

Synthesis and TNF-α inducing activities of mycoloyl-arabinan motif of mycobacterial cell wall components

Akihiro Ishiwata, Hiroko Akao, Yukishige Ito, +3

Bioorganic & Medicinal Chemistry

BiosynthesisBiochemistryTnf-α Inducing ActivitiesNatural SciencesMycoloyl-arabinan Motif +5

Synthetic approach to bacterial lipopolysaccharide, preparation of trisaccharide part structures containing KDO and 1-dephospho lipid A

Masahiro Imoto, Naoto Kusunose, Shoichi Kusumoto, +1

Tetrahedron Letters

Lipid PreparationEngineeringBiotechnologySynthetic ApproachPolysaccharide +5

Antimetastatic Activity of Polymeric RGDT Peptides Conjugated with Poly(ethylene glycol)

Ikuo Saiki, Junya Yoneda, Yu Igarashi, +4

Japanese Journal of Cancer Research

Comprehensive analysis of mycolic acid subclass and molecular species composition of Mycobacterium bovis BCG Tokyo 172 cell wall skeleton (SMP-105)

Yuko Uenishi, Yukiko Fujita, Naoto Kusunose, +2

Journal of Microbiological Methods

BiochemistryNatural SciencesBacteriologyMolecular BiologyTuberculosis +7

Chemical synthesis of 1-dephospho derivative of escherichia coli re lipopolysaccharide

Shoichi Kusumoto, Naoto Kusunose, Takashi Kamikawa, +1

Tetrahedron Letters

BiosynthesisEngineeringBiochemistryNatural SciencesBiocatalysis +6

Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution

Kazuto Yamazaki, Naoto Kusunose, Katsuya Fujita, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryVirtual ScreeningHit IdentificationDrug TargetBiochemistry +11

Arabino-mycolates derived from cell-wall skeleton of <i>Mycobacterium bovis</i> BCG as a prominent structure for recognition by host immunity

Masanori Miyauchi, Masashi Murata, Keiko Shibuya, +6

Drug Discoveries & Therapeutics

Pathogenic MicrobiologyMicrobial PathogensBacteriologyImmune RegulationGlycobiology +20