Takaaki Shiyama

A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

Daisuke Tanaka, Yusuke Tsuda, Takaaki Shiyama et al. · Journal of Medicinal Chemistry · 2010 · 72 citations · Full text

Bioorganic Chemistry, Hit Identification, Ligand Efficiency +18

Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins

Takaaki Shiyama, Minoru Furuya, Akira Yamazaki et al. · Bioorganic & Medicinal Chemistry · 2004 · 50 citations

Biochemistry, Protein Folding, Natural Sciences +8

Macrophage Activation in Response to S-Form Lipopolysaccharides (LPS) Separated by Centrifugal Partition Chromatography from Wild-Type LPS: Effects of the O-Polysaccharide Portion of LPS

Yasuo Suda, Teruo Kirikae, Takaaki Shiyama et al. · Biochemical and Biophysical Research Communications · 1995 · 25 citations

Inflammation, Lipid Analysis, Biochemistry +10

Synthesis and biological activity of a model disaccharide containing a key unit in heparin for binding to platelets

Yasuo Suda, Karyn E. Bird, Takaaki Shiyama et al. · Tetrahedron Letters · 1996 · 22 citations

Biological Activity, Key Unit, Biochemistry +7

Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins

Teruki Takahashi, Takaaki Shiyama, Ken Hosoya et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 22 citations

Protein Chemistry, Biochemistry, Protein Assembly +6