BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang, +23

Cancer Research

Mutant BrafRaf/mek/erk PathwayMedicineTumor GrowthMutant Kras +10

Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5

Li Liu, Yichen Cao, Charles Chen, +6

Cancer Research

Chemoprevention StrategyImmunologyCell DeathRaf/mek/erk PathwayTumor Biology +17

Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models

Yong S. Chang, Jalila Adnane, Pamela A. Trail, +12

Cancer Chemotherapy and Pharmacology

OncologyMedicineTumor GrowthCell DeathRcc Xenograft Models +8

Phase II Trial of Sorafenib in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Nasopharyngeal Carcinoma

Christine Elser, Lillian L. Siu, Eric Winquist, +10

Journal of Clinical Oncology

BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

Ningshu Liu, Bruce R. Rowley, Cathy Bull, +10

Molecular Cancer Therapeutics

Molecular PharmacologyTumor BiologyPi3k InhibitorsMedicineXenograft Models +13

Antitumor activity of sorafenib in FLT3-driven leukemic cells

Daniel Auclair, David F. Miller, Victoria Yatsula, +15

Leukemia

Tumor BiologyAntitumor ActivityMedicineAnti-cancer AgentCancer Biology +2

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

Timothy P. LaBranche, Michael I. Jesson, Chad Storer, +17

Arthritis & Rheumatism

Discovery and SAR of Novel 2,3‐Dihydroimidazo[1,2‐<i>c</i>]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80‐6946)

William J. Scott, Martin Hentemann, R. Rowley, +20

ChemMedChem

Morphological and structural characteristics of the proximal femur in human and rat

Cedo M. Bagi, Dean Wilkie, K. Georgelos, +2

Bone

Structural CharacteristicsAxial SkeletonProximal FemurPhysiologyBiomechanics +8

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

Cedo M. Bagi, James R. Christensen, Darrel P. Cohen, +5

Cancer Biology & Therapy