T-cell activation is an immune correlate of risk in BCG vaccinated infants

Helen A. Fletcher, Margaret Ann Snowden, Bernard Landry, +27

Nature Communications

Cytomegalovirus infection is a risk factor for tuberculosis disease in infants

Julius Müller, Rachel Tanner, Magali Matsumiya, +23

JCI Insight

Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb)

Leanne Marsay, Magali Matsumiya, Rachel Tanner, +8

Tuberculosis

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Eileen McNeill, Elena Stylianou, Mark J. Crabtree, +14

Nature Communications

Gene Expression and Cytokine Profile Correlate With Mycobacterial Growth in a Human BCG Challenge Model

Magali Matsumiya, Iman Satti, Agnieszka Chomka, +5

The Journal of Infectious Diseases

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Rachel Tanner, Matthew K. O’Shea, Andrew White, +13

Scientific Reports

Tools for Assessing the Protective Efficacy of TB Vaccines in Humans: in vitro Mycobacterial Growth Inhibition Predicts Outcome of in vivo Mycobacterial Infection

Rachel Tanner, Iman Satti, Stephanie A. Harris, +10

Frontiers in Immunology

Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection

Matthew K. O’Shea, Julius Müller, Rachel Tanner, +11

Frontiers in Immunology

Roles for Treg Expansion and HMGB1 Signaling through the TLR1-2-6 Axis in Determining the Magnitude of the Antigen-Specific Immune Response to MVA85A

Magali Matsumiya, Elena Stylianou, Kristin Griffiths, +8

PLoS ONE

Tlr1-2-6 AxisAdaptive Immune SystemT-regulatory CellImmunologyAntigen Processing +18

Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults

Rosalind Rowland, Ansar A. Pathan, Iman Satti, +16

Human Vaccines & Immunotherapeutics

VaccinationPulmonary TuberculosisVaccine DevelopmentSubsequent Mva85aCandidate Tb Vaccine +12