Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

Xia Zhou, Lucy X. Fan, William E. Sweeney, +3

Journal of Clinical Investigation

Renal PathologyRenal InflammationPathologyCyst GrowthNephrology +18

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

Li Chen, Xia Zhou, Lucy X. Fan, +8

Journal of Clinical Investigation

Renal PathologyImmunologyRenal InflammationPathologyCell Death +19

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

Xiaoyan Li, Lucy X. Fan, Julie Zhou, +4

Journal of Clinical Investigation

GeneticsRenal PathologyRenal InflammationPathologyCyst Growth +22

HDAC6 Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation in Renal Epithelial Cells

Wei Liu, Lucy X. Fan, Xia Zhou, +3

PLoS ONE

Renal PathologyCytoskeletonHdac ActivityEndocytic TraffickingCellular Physiology +18

Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation

Lucy X. Fan, Xinjian Li

Kidney International

Histone ModificationsChromatinTranscriptional RegulationSystems BiologyTranscription Regulator Id2 +9

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1

Xia Zhou, Lucy X. Fan, Keguo Li, +3

Human Molecular Genetics

ChromatinDevelopmental BiologySignal TransductionCell DivisionAbnormal Centrosome Amplification +11

Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD

Xia Zhou, Lucy X. Fan, Dorien J.M. Peters, +3

Human Molecular Genetics

ImmunologyCyst GrowthCell ProliferationSignaling PathwayCell Regulation +15

Smac-Mimetic–Induced Epithelial Cell Death Reduces the Growth of Renal Cysts

Lucy X. Fan, Xia Zhou, William E. Sweeney, +4

Journal of the American Society of Nephrology

Renal PathologyImmunologyRenal InflammationCell DeathPathology +24

TNFα Signaling Regulates Cystic Epithelial Cell Proliferation through Akt/mTOR and ERK/MAPK/Cdk2 Mediated Id2 Signaling

Julie Zhou, Lucy X. Fan, Xiaoyan Li

PLoS ONE

Inflammatory Lung DiseaseRenal PathologyImmune RegulationImmunologyPathology +19

A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition

Eoghainín Ó hAinmhire, Yoshiharu Muto, Erinn L. Donnelly, +4

American Journal of Physiology-Renal Physiology

Glioma-associated Oncogene Homolog-1Cell ProliferationCancer BiologyGliomaCellular Physiology +19