Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and <i>In vivo</i> Models for Intestinal and Prostate Cancer

Holly Symolon, Anatoliy Bushnev, Qiong Peng, +8

Molecular Cancer Therapeutics

Chemoprevention StrategyCancer BiologyTumor BiologyGastrointestinal OncologyCancer Cell Biology +18

Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer

Ethel C. Garnier‐Amblard, Suzanne G. Mays, Richard F. Arrendale, +13

ACS Medicinal Chemistry Letters

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists

Suzanne G. Mays, C. Denise Okafor, Richard J. Whitby, +7

Journal of Biological Chemistry

Molecular BiologyMolecular PharmacologySignaling PathwaySynthetic AgonistsReceptor Tyrosine Kinase +19

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

Suzanne G. Mays, Autumn R. Flynn, Jeffery L. Cornelison, +11

Journal of Medicinal Chemistry

EngineeringBiomedical EngineeringNanomedicinePolar InteractionMolecular Physiology +15

Atomic-Level Mechanism of Pre-mRNA Splicing in Health and Disease

Jure Borišek, Lorenzo Casalino, Andrea Saltalamacchia, +3

Accounts of Chemical Research

Structure and Dynamics of the Liver Receptor Homolog 1–PGC1α Complex

Suzanne G. Mays, C. Denise Okafor, Micheal L. Tuntland, +5

Molecular Pharmacology

Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1

Autumn R. Flynn, Suzanne G. Mays, Eric A. Ortlund, +1

ACS Medicinal Chemistry Letters

Proteinlipid InteractionDrug TargetChemical BiologyMedicinal ChemistryCell Signaling +18

Discovery of a Fluorinated Enigmol Analog with Enhanced <i>in Vivo</i> Pharmacokinetic and Anti-Tumor Properties

Eric J Miller, Suzanne G. Mays, Mark T. Baillie, +12

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceEnigmol AnalogsAnti-tumor PropertiesPharmacotherapyPharmaceutical Chemistry +15

Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

Jeffery L. Cornelison, Michael L. Cato, Alyssa M. Johnson, +7

Bioorganic & Medicinal Chemistry Letters

OptogeneticsLiver Receptor Homolog-1Signal TransductionBiochemistryG Protein-coupled Receptor +10

A phospholipid mimetic targeting LRH-1 ameliorates colitis

Suzanne G. Mays, Emma H. D’Agostino, Autumn R. Flynn, +14

Cell chemical biology

InflammationAnti-inflammatoryMedicineImmunologyLrh-1 Ameliorates Colitis +2