Synthesis and Biological Evaluation of 2,3,5-Substituted [1,2,4]Thiadiazoles as Allosteric Modulators of Adenosine Receptors

Adrianus M. C. H. van den Nieuwendijk, Daniele Pietra, Laura H. Heitman, +2

Journal of Medicinal Chemistry

Allosteric ModulatorsAdenosine ReceptorsPharmacotherapyExperimental PharmacologyPharmaceutical Chemistry +14

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Simona Sestito, Giulia Nesi, Simona Daniele, +12

European Journal of Medicinal Chemistry

Neuro-oncologyMedicinal ChemistryGliomaGlioblastoma MultiformeMedicine +8

Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers

Anikó Göblyös, Sabrina Neves Santiago, Daniele Pietra, +4

Bioorganic & Medicinal Chemistry

Molecular PharmacologyAllosteric EnhancersBiochemistryMedicineMechanism Of Action +7

Synthesis, biological activity and molecular modelling of new trisubstituted 8-azaadenines with high affinity for A1 adenosine receptors

Irene Giorgi, Anna Maria Bianucci, Giuliana Biagi, +9

European Journal of Medicinal Chemistry

Biological ActivityCombinatorial ChemistryBiochemistryMedicineNatural Sciences +6

N6-1,3-Diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors

Irene Giorgi, Giuliana Biagi, Anna Maria Bianucci, +6

European Journal of Medicinal Chemistry

Allosteric ModulatorsA2a Adenosine ReceptorsBiochemistryMedicinePharmacological Agent +5

QSAR study on thiazole and thiadiazole analogues as antagonists for the adenosine A1 and A3 receptors

Alice Borghini, Daniele Pietra, Patrick Domenichelli, +1

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAdenosine A1BiochemistryFunctional SelectivityMedicine +8

Berberine exposure triggers developmental effects on planarian regeneration

Linda Balestrini, Maria Emilia Isolani, Daniele Pietra, +4

Scientific Reports

The in vivo effect of chelidonine on the stem cell system of planarians

Maria Emilia Isolani, Daniele Pietra, Linda Balestrini, +5

European Journal of Pharmacology

Developmental BiologyStem Cell SystemMedicineVivo EffectStem Cell Toxicology +4

In vitro studies of antifibrotic and cytoprotective effects elicited by proto-berberine alkaloids in human dermal fibroblasts

Daniele Pietra, Alice Borghini, Anna Maria Bianucci

Pharmacological Reports

Cytoprotective EffectsMedicineHerbal MedicineHerb-drug InteractionPathology +4

Data mining as a predictive model for Chelidonium majus extracts production

Alice Borghini, Daniele Pietra, Claudia di Trapani, +3

Industrial Crops and Products

Evolutionary Data MiningPredictive ModelEngineeringData ScienceBotany +8