Galith Karoutchi

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and <i>ESR1</i> -Mutant Breast Tumors in Preclinical Models

Hazel M. Weir, Robert H. Bradbury, Mandy Lawson et al. · Cancer Research · 2016 · 174 citations

Medicine, Oncology, Pharmacology +16

Optimization of a Novel Binding Motif to (<i>E</i>)-3-(3,5-Difluoro-4-((1<i>R</i>,3<i>R</i>)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1<i>H</i>-pyrido[3,4-<i>b</i>]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

Chris De Savi, Robert H. Bradbury, Alfred A. Rabow et al. · Journal of Medicinal Chemistry · 2015 · 160 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode

M. Raymond V. Finlay, David Acton, David Andrews et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design of selective Cathepsin inhibitors

Paul A. Bethel, S. Gerhardt, Emma V. Jones et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Selective non zinc binding inhibitors of MMP13

Chris De Savi, Andrew Morley, Attilla Ting et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11