Prostaglandin E2–EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation

Kazushi Morimoto, Naritoshi Shirata, Yoshitaka Taketomi, +8

The Journal of Immunology

Mast Cell DisorderImmune RegulationImmunologyCell DeathPge2 Triggers +16

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2–DP1 receptor paracrine axis

Yoshitaka Taketomi, Noriko Ueno, Takumi Kojima, +30

Nature Immunology

Developmental BiologySignal TransductionMast Cell MaturationSignaling PathwayG Protein-coupled Receptor +9

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, +30

Nature Chemical Biology

Proteinlipid InteractionSignal TransductionLipid-bilayer InterfaceBiochemistryG Protein-coupled Receptor +5

Crystal structure of the endogenous agonist-bound prostanoid receptor EP3

Kazushi Morimoto, Ryoji Suno, Yunhong Hotta, +6

Nature Chemical Biology

Molecular PharmacologyCrystal StructureBiochemistryG Protein-coupled ReceptorMedicine +3

Antrimycin, a new peptide antibiotic.

NOBUYOSHI SHIMADA, Kazushi Morimoto, HIROSHI NAGANAWA, +5

The Journal of Antibiotics

Medicinal ChemistryAntimicrobial Drug DiscoveryNew PeptideAntibioticsMedicine +6

Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis

Naoya Yamada, Tadayoshi Karasawa, Junya Ito, +17

Nature Communications

Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization

Yuma Saimoto, Daiki Kusakabe, Kazushi Morimoto, +13

Nature Communications

Proteinlipid InteractionFluorescent Detection ProbesBiochemistryNatural SciencesLipid Peroxidation +13

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Shingo Nojima, Yoko Fujita, Kanako Kimura, +8

Structure

Molecular PharmacologyProtein FunctionSignal TransductionMolecular PhysiologyBiochemistry +9

Prostaglandin E2-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism

Tomoaki Inazumi, Naritoshi Shirata, Kazushi Morimoto, +3

Journal of Lipid Research

RhoA/Rho Kinase Signaling in the Cumulus Mediates Extracellular Matrix Assembly

Rieko Yodoi, Shigero Tamba, Kazushi Morimoto, +5

Endocrinology