Lisa Hettrick

The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human

Yunhui Wu, Alice E. Loper, Elizabeth Landis et al. · International Journal of Pharmaceutics · 2004 · 272 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

Michael Tanowitz, Lisa Hettrick, Alexey S. Revenko et al. · Nucleic Acids Research · 2017 · 160 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

Alexey S. Revenko, Larissa S. Carnevalli, Charles Sinclair et al. · Journal for ImmunoTherapy of Cancer · 2022 · 86 citations · Full text

Medicine, Immunology, Oncology +16

Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti–PD-1 in Metastatic Non–Small Cell Lung Cancer

Kewen He, Hampartsoum B. Barsoumian, Nahum Puebla‐Osorio et al. · Cancer Immunology Research · 2023 · 51 citations · Full text

Life Sciences, Immunology, Oncology +17

Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B₁ Receptor Antagonists

Michael R. Wood, Kathy M. Schirripa, June J. Kim et al. · Journal of Medicinal Chemistry · 2006 · 41 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13