Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration

Hiroshi Nagase, Toru Nemoto, Ayaka Matsubara, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyFunctional SelectivityMedicineδ-Opioid Receptor AgonistMechanism Of Action +8

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator

Yoshiyuki Meguro, Kanako Miyano, Shigeto Hirayama, +13

Journal of Pharmacological Sciences

Usefulness of Olanzapine as an Adjunct to Opioid Treatment and for the Treatment of Neuropathic Pain

Kazuhiro Torigoe, Kae Nakahara, Mahardian Rahmadi, +13

Anesthesiology

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Hiroshi Nagase, Naoshi Yamamoto, Masahiro Yata, +13

Journal of Medicinal Chemistry

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists

Yoshihiro Ida, Toru Nemoto, Shigeto Hirayama, +7

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicineMechanism Of ActionPharmacological AgentNeuropharmacology +4

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

Yoshihiro Ida, Ayaka Matsubara, Toru Nemoto, +4

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryQuinolinomorphinan DerivativesMedicineFunctional Selectivity +7

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists

Toru Nemoto, Yusuke Iihara, Shigeto Hirayama, +4

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFluorinated Ethyl SubstituentsMedicineMechanism Of Action +7

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies

Hiroshi Nagase, Satomi Imaide, Shigeto Hirayama, +2

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPhenanthrene DerivativesBiochemistryMedicineEssential Structure +6

Effects of mirtazapine on sleep disturbance under neuropathic pain‐like state

Tatsuya Enomoto, Akira Yamashita, Kazuhiro Torigoe, +11

Synapse

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives

Toru Nemoto, Naoshi Yamamoto, Naohisa Wada, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicine17-N SubstituentsMechanism Of Action +6