Charlene M. Downey

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

Bryan Heit, Stephen M. Robbins, Charlene M. Downey et al. · Nature Immunology · 2008 · 281 citations

Inflammation, Signal Transduction, Granulocyte +12

DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization

Charlene M. Downey, Mehrnoosh Aghaei, Reto A. Schwendener et al. · PLoS ONE · 2014 · 201 citations · Full text

Inflammation, Cytokine, Cancer Immunosurveillance +15

The Lysyl Oxidase Inhibitor, β-Aminopropionitrile, Diminishes the Metastatic Colonization Potential of Circulating Breast Cancer Cells

Alla Bondareva, Charlene M. Downey, Fábio J. Ayres et al. · PLoS ONE · 2009 · 156 citations · Full text

Lysyl Oxidase Inhibitor, Breast Oncology, Medicine +15

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

Charlene M. Downey, Chelsea R. Horton, Bradley A. Carlson et al. · PLoS Genetics · 2009 · 112 citations · Full text

Sclerostin, Genetics, Pathology +20

Mind the Gap: Genetic Manipulation of Basicranial Growth within Synchondroses Modulates Calvarial and Facial Shape in Mice through Epigenetic Interactions

Trish E. Parsons, Charlene M. Downey, Frank R. Jirik et al. · PLoS ONE · 2015 · 55 citations · Full text

Cartilage Growth, Epigenetic Change, Genetics +25