Gilles Ouvry

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2<i>H</i>-pyran-4-yl)-1,3-dihydro-2<i>H</i>-imidazo[4,5-<i>c</i>]quinolin-2-one)

Kurt G. Pike, Bernard Barlaam, Elaine Cadogan et al. · Journal of Medicinal Chemistry · 2018 · 111 citations · Full text

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3<i>R</i>)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

Robert H. Bradbury, Rowena Callis, Gregory R. Carr et al. · Journal of Medicinal Chemistry · 2016 · 85 citations · Full text

Pharmaceutical Science, Chemoprevention Strategy, Organic Chemistry +21

Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Sébastien L. Degorce, Bernard Barlaam, Elaine Cadogan et al. · Journal of Medicinal Chemistry · 2016 · 73 citations · Full text

Bioorganic Chemistry, Molecular Biology, Pharmacotherapy +18

α-Scission of sulfonyl radicals: a versatile process for organic synthesis

Frédérique Bertrand, Frédéric Le Guyader, Lucia Liguori et al. · Comptes Rendus de l Académie des Sciences - Series IIC - Chemistry · 2001 · 40 citations

Sulfonyl Radicals, Engineering, Radical (Chemistry) +5

Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists

Gilles Ouvry, Claire Bouix‐Peter, Fabrice Ciesielski et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 37 citations · Full text

Molecular Pharmacology, Drug Target, Medicine +6