Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, +32

Nature

InflammationReductive StressAnti-inflammatoryAllergyAnti-inflammatory Metabolite +8

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

Christopher J. Oliphant, You Yi Hwang, Jennifer A. Walker, +10

Immunity

InflammationGroup 2Autoimmune DiseaseAllergyPathogenesis +11

Transcription factor RORα is critical for nuocyte development

See Heng Wong, Jennifer A. Walker, Helen E. Jolin, +12

Nature Immunology

Transcription Factor RorαTranscriptional RegulationTranscription FactorsDevelopmental BiologyGenetics +5

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

Ceri A. Fielding, Gareth W. Jones, Rachel M. McLoughlin, +24

Immunity

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

Emily Hams, Michelle E. Armstrong, Jillian L. Barlow, +11

Proceedings of the National Academy of Sciences

PD-L1hi B cells are critical regulators of humoral immunity

Adnan R. Khan, Emily Hams, Achilleas Floudas, +3

Nature Communications

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung

Ismé M. de Kleer, Mirjam Kool, Marjolein J. W. de Bruijn, +10

Immunity

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, +22

Cell Metabolism

InflammationItaconate DerivativesAlternative ActivationCytokineAutoimmune Disease +11

The Schistosoma Granuloma: Friend or Foe?

Emily Hams, Gabriella Aviello, Padraic G. Fallon

Frontiers in Immunology

Parasitic DiseaseSchistosoma GranulomaAutoimmune DiseaseMedicinePathogenesis +9

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

Emily Hams, Richard M. Locksley, Andrew N. J. McKenzie, +1

The Journal of Immunology