Tohko Arai

Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with β-lactam antibiotics

Masahito Horiuchi, Megumi Kimura, Miwa Tokumura et al. · Toxicology · 2006 · 91 citations

Life Sciences, Pharmacology, Pharmacotherapy +16

Effect of Intrathecal Nocistatin on the Formalin-Induced Pain in Mice Versus That of Nociceptin/Orphanin FQ

Hiroyuki Nakano, Toshiaki Minami, Kohji Abe et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 44 citations

Medicine, Neurobiology, Pharmacology +17

Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

Toshiyuki Kanemasa, Katsumi Koike, Tohko Arai et al. · Neurogastroenterology & Motility · 2019 · 36 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Pharmacological Profile of Naldemedine, a Peripherally Acting μ-Opioid Receptor Antagonist: Comparison with Naloxone and Naloxegol

Toshiyuki Kanemasa, Katsumi Koike, Kenji Takase et al. · Journal of Pharmacology and Experimental Therapeutics · 2020 · 35 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: Discovery of CB2 receptor selective compounds

Hiroyuki Kai, Yasuhide Morioka, Takami Murashi et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10