Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Ying-Ren Wang, Shin-Fu Chen, Chyuan-Chuan Wu, +7

Nucleic Acids Research

Drug TargetFlanking MethionineApoptosisMolecular BiologyCell Death +18

RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability

Feng Xiong, Ruoyu Wang, Joo‐Hyung Lee, +12

Cell Research

Structural basis of antizyme-mediated regulation of polyamine homeostasis

Hsiang-Yi Wu, Shin-Fu Chen, Ju‐Yi Hsieh, +12

Proceedings of the National Academy of Sciences

One-Pot Synthesis of Hollow Au₃Cu₁ Spherical-like and Biomineral Botallackite Cu₂(OH)₃Cl Flowerlike Architectures Exhibiting Antimicrobial Activity

Min‐Tien Hsiao, Shin-Fu Chen, Dar‐Bin Shieh, +1

The Journal of Physical Chemistry B

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

Shin-Fu Chen, Nan-Lan Huang, Jung‐Hsin Lin, +5

Nature Communications

Reactivity of Laser-Prepared Copper Nanoparticles:  Oxidation of Thiols to Disulfides

Tung-Yu Chen, Shin-Fu Chen, Hwo‐Shuenn Sheu, +1

The Journal of Physical Chemistry B

Materials ScienceLaser-prepared Copper NanoparticlesCu IdentityEngineeringLaser Photochemistry +12

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

Yi‐Chuan Li, Ti‐Chun Chao, Hee Jong Kim, +10

Science Advances

A machine learning algorithm for predicting prolonged postoperative opioid prescription after lumbar disc herniation surgery. An external validation study using 1,316 patients from a Taiwanese cohort

Hung‐Kuan Yen, Paul T. Ogink, Chuan‐Ching Huang, +16

The Spine Journal

Taiwanese CohortPain MedicineMachine Learning AlgorithmPredictive AnalyticsPatient Safety +12

Structural basis of a transcription pre-initiation complex on a divergent promoter

Jose J. Gorbea Colón, Leon Palao, Shin-Fu Chen, +5

Molecular Cell

Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module

Ti‐Chun Chao, Shin-Fu Chen, Hee Jong Kim, +11

Molecular Cell

ChromatinTranscriptional RegulationSignal TransductionSignaling PathwayMolecular Regulation +12