Nonsteroidal Selective Glucocorticoid Modulators:  The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Philip R. Kym, Michael E. Kort, Michael J. Coghlan, +17

Journal of Medicinal Chemistry

Functional PotencyMedicinal ChemistryC-10 SubstitutionBiochemistryG Protein-coupled Receptor +12

Default-Mode-Like Network Activation in Awake Rodents

Jaymin Upadhyay, Scott Baker, Prasant Chandran, +8

PLoS ONE

Indol-3-yl-tetramethylcyclopropyl Ketones: Effects of Indole Ring Substitution on CB₂ Cannabinoid Receptor Activity

Jennifer M. Frost, Michael J. Dart, Karin Tietje, +12

Journal of Medicinal Chemistry

Molecular PainCannabinoid PharmacologyMolecular PharmacologyMedicinal ChemistryCb 2 +14

Structure−Activity Relationship of Triazafluorenone Derivatives as Potent and Selective mGluR1 Antagonists

Guo Zhu Zheng, Pramila Bhatia, Jerome F. Daanen, +13

Journal of Medicinal Chemistry

Molecular PainPharmacotherapyTriazafluorenone DerivativesMolecular PharmacologyMedicinal Chemistry +15

Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1 <i>H</i> -benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction

Marlon Cowart, Steven P. Latshaw, Pramila Bhatia, +20

Journal of Medicinal Chemistry

A-350619: A novel activator of soluble guanylyl cyclase

Loan Miller, Masaki Nakane, Gin C. Hsieh, +4

Life Sciences

BiochemistryNatural SciencesSoluble Guanylyl CyclaseChemical BiologyEnzymatic Modification

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Steven W. Elmore, John K. Pratt, Michael J. Coghlan, +11

Bioorganic & Medicinal Chemistry Letters

Activation ProfilesSelective Glucocorticoid ModulatorsTranscriptional RegulationGeneticsGene Regulation +6

Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A‐841720, a novel non‐competitive mGluR1 receptor antagonist

Odile F. El-Kouhen, Sonya G. Lehto, Jia Bao Pan, +22

British Journal of Pharmacology

trans-Activation and Repression Properties of the Novel Nonsteroid Glucocorticoid Receptor Ligand 2,5-Dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and Its Four Stereoisomers

Chun Wel Lin, Masaki Nakane, Mike Stashko, +11

Molecular Pharmacology

Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1

Masaki Nakane, Gin C. Hsieh, Loan Miller, +5

International Journal of Impotence Research

Nitric OxideMedicinePhysiologyNeuroscienceNervous System +3