The immune landscape in tuberculosis reveals populations linked to disease and latency

Ekaterina Esaulova, Shibali Das, Dhiraj Kumar Singh, +18

Cell Host & Microbe

Pulmonary TuberculosisHost FactorPathogenesisImmunologyTuberculosis Prevention +7

Pharmacokinetics and Pharmacodynamics of Clofazimine in a Mouse Model of Tuberculosis

Rosemary V. Swanson, John Adamson, Chivonne Moodley, +10

Antimicrobial Agents and Chemotherapy

Tuberculosis PreventionBactericidal ActivityPharmacotherapyAntimicrobial ChemotherapyExperimental Pharmacology +17

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Shannon Russell, Dirk A. Lamprecht, Tawanda Mandizvo, +8

Cell Reports

Clofazimine has delayed antimicrobial activity against<i>Mycobacterium tuberculosis</i>both<i>in vitro</i>and<i>in vivo</i>

Nicole C. Ammerman, Rosemary V. Swanson, Asa Tapley, +10

Journal of Antimicrobial Chemotherapy

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

Dhiraj Kumar Singh, Ekaterina Aladyeva, Shibali Das, +11

Nature Communications

Impact of Clofazimine Dosing on Treatment Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis

Nicole C. Ammerman, Rosemary V. Swanson, Elaine M. Bautista, +18

Antimicrobial Agents and Chemotherapy

Pulmonary TuberculosisPharmacological StudyMedicineImmunologyAntimicrobial Resistance +12

Clofazimine Contributes Sustained Antimicrobial Activity after Treatment Cessation in a Mouse Model of Tuberculosis Chemotherapy

Rosemary V. Swanson, Nicole C. Ammerman, Bongani Ngcobo, +9

Antimicrobial Agents and Chemotherapy

Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy

Bindu Singh, Chivonne Moodley, Dhiraj Kumar Singh, +11

JCI Insight

Tuberculosis PreventionImmunologyPharmacotherapyImmunotherapeuticsAntimicrobial Chemotherapy +20

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain

Sooraj Baijnath, Adeola Shobo, Chivonne Moodley, +7

Journal of Molecular Histology

NeuropsychologyPsychoactive DrugHealthy Mouse BrainPsychiatryNeurophysiology +12

Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts <i>Mycobacterium tuberculosis</i> Pathogenicity

Allison N. Bucşan, Ashley V. Veatch, Dhiraj Kumar Singh, +15

American Journal of Respiratory and Critical Care Medicine