Joseph R. Herdy

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

Jérôme Mertens, Apuã C.M. Paquola, Manching Ku et al. · Cell stem cell · 2015 · 717 citations · Full text

Lifespan Extension, Neurodegenerative Diseases, Molecular Neuroscience +10

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Ana Jovičić, Jérôme Mertens, Steven Boeynaems et al. · Nature Neuroscience · 2015 · 616 citations · Full text

Nucleocytoplasmic Transport Defects, Amyotrophic Lateral Sclerosis, Biochemistry +4

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Jérôme Mertens, Joseph R. Herdy, Larissa Traxler et al. · Cell stem cell · 2021 · 233 citations · Full text

L1-associated genomic regions are deleted in somatic cells of the healthy human brain

Jennifer A. Erwin, Apuã C.M. Paquola, Tatjana Singer et al. · Nature Neuroscience · 2016 · 200 citations · Full text

Molecular Neuroscience, Neurogenomics, Ependyma +10

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Joseph R. Herdy, Larissa Traxler, Ravi Kant Agarwal et al. · Cell stem cell · 2022 · 170 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Aging +11