Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

Jamie E. Craig, Xikun Han, Ayub Qassim, +56

Nature Genetics

Genome-wide Association StudyDisease SusceptibilityMedicineGeneticsMultitrait Analysis +10

Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA

Xikun Han, Kaiah Steven, Ayub Qassim, +10

The American Journal of Human Genetics

NeurogenomicsOphthalmologyOptic Nerve HeadGeneticsCross-ancestry Glaucoma Risk +10

Corneal Stiffness Parameters Are Predictive of Structural and Functional Progression in Glaucoma Suspect Eyes

Ayub Qassim, Sean Mullany, Farshad Abedi, +17

Ophthalmology

OphthalmologyCorneal DystrophyFunctional ProgressionOcular TissueGlaucoma +3

Cardiovascular Disease Predicts Structural and Functional Progression in Early Glaucoma

Henry Marshall, Sean Mullany, Ayub Qassim, +17

Ophthalmology

Ocular DiseaseOphthalmologyPhysiologyEarly GlaucomaEye Health +3

Macular Ganglion Cell–Inner Plexiform Layer Loss Precedes Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma with Lower Intraocular Pressure

Henry Marshall, Nicholas H. Andrew, Mark Hassall, +15

Ophthalmology

Retinal BiologyGanglion CellRetinaOphthalmologyGlaucoma +3

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma

Owen M. Siggs, Ayub Qassim, Xikun Han, +13

JAMA Ophthalmology

Association Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts

Henry Marshall, Ella C. Berry, Santiago Díaz‐Torres, +22

American Journal of Ophthalmology

Ocular DiseaseBody CompositionOphthalmologyEye HealthThree Cohorts +3

Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma

Owen M. Siggs, Xikun Han, Ayub Qassim, +9

JAMA Ophthalmology

High Polygenic Risk Is Associated with Earlier Initiation and Escalation of Treatment in Early Primary Open-Angle Glaucoma

Henry Marshall, Sean Mullany, Xikun Han, +22

Ophthalmology

UrologyOcular DiseaseOphthalmologyEarlier InitiationEye Health +2

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

Mona S. Awadalla, Jude Fitzgerald, Nicholas H. Andrew, +13

PLoS ONE