Jeffrey A. Deskus

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5<i>H</i>-benzo[5,6]cyclohepta[1,2-<i>b</i>]- pyridin-11(<i>R</i>)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336):  A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

F. George Njoroge, Arthur G. Taveras, Joseph Kelly et al. · Journal of Medicinal Chemistry · 1998 · 97 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Synthesis and structure–activity relationship of novel benzoxazole derivatives as melatonin receptor agonists

Li‐Qiang Sun, Jie Chen, Marc A. Bruce et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 89 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Tricyclic Farnesyl Protein Transferase Inhibitors:  Crystallographic and Calorimetric Studies of Structure−Activity Relationships

Corey L. Strickland, Patricia C Weber, William T. Windsor et al. · Journal of Medicinal Chemistry · 1999 · 88 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

A Strategy to Minimize Reactive Metabolite Formation: Discovery of (<i>S</i>)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

Richard A. Hartz, Vijay T. Ahuja, Xiaoliang Zhuo et al. · Journal of Medicinal Chemistry · 2009 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors

Jeffrey A. Deskus, James R. Epperson, C.P. Sloan et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 40 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16