David Depoil

CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

David Depoil, Sebastian J. Fleire, Bebhinn Treanor et al. · Nature Immunology · 2007 · 349 citations

Adaptive Immune System, Membrane-bound Ligand, Immunology +10

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

Pieta K. Mattila, Christoph Feest, David Depoil et al. · Immunity · 2013 · 330 citations · Full text

Signal Transduction, Signaling Pathway, G Protein-coupled Receptor +8

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

Bebhinn Treanor, David Depoil, Aitor Gonzalez-Granja et al. · Immunity · 2010 · 320 citations · Full text

Cytoskeleton, Cellular Physiology, Bcr Diffusion +19

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Alexandra Zanin‐Zhorov, Jonathan M. Weiss, Melanie Nyuydzefe et al. · Proceedings of the National Academy of Sciences · 2014 · 244 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +24

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Sudha Kumari, David Depoil, Roberta Martinelli et al. · eLife · 2015 · 190 citations · Full text