Aleksas Matvekas

Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

Weiguo Xiang, Lijie Zhao, Xin Han et al. · Journal of Medicinal Chemistry · 2021 · 140 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer

Xin Han, Lijie Zhao, Weiguo Xiang et al. · Journal of Medicinal Chemistry · 2021 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes

Rebecca Reed Moody, Miao‐Chia Lo, Jennifer L. Meagher et al. · Journal of Biological Chemistry · 2017 · 70 citations · Full text

Medicine, Molecular Biology, Oncology +16

Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

Xin Han, Lijie Zhao, Weiguo Xiang et al. · Journal of Medicinal Chemistry · 2023 · 53 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer

Zhixiang Chen, Mi Wang, Dimin Wu et al. · Journal of Medicinal Chemistry · 2024 · 35 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15