David Leggett

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

Bruce Campbell, Peter Mitchell, Leonid Churilov et al. · New England Journal of Medicine · 2018 · 817 citations · Full text

Multiple Associated Proteins Regulate Proteasome Structure and Function

David Leggett, John Hanna, Anna Borodovsky et al. · Molecular Cell · 2002 · 639 citations · Full text

Protein Function, Natural Sciences, Proteasome +4

Proteasome subunit Rpn1 binds ubiquitin-like protein domains

Suzanne Elsasser, Rayappa R. Gali, Martin Schwickart et al. · Nature Cell Biology · 2002 · 466 citations

Protein Function, Protein Assembly, Proteasome Subunit Rpn1 +5

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

Youzhi Li, Harry A. Rogoff, Sarah Keates et al. · Proceedings of the National Academy of Sciences · 2015 · 451 citations · Full text

Cancer Relapse, Cancer Biology, Tumor Biology +16

The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

Alwin Köhler, Paolo Cascio, David Leggett et al. · Molecular Cell · 2001 · 413 citations · Full text

Protein Secretion, Protein Function, Biochemistry +13