David Leggett

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

Bruce Campbell, Peter Mitchell, Leonid Churilov et al. · New England Journal of Medicine · 2018 · 855 citations · Full text

Medicine, Neurological Surgery, Surgery +16

Multiple Associated Proteins Regulate Proteasome Structure and Function

David Leggett, John Hanna, Anna Borodovsky et al. · Molecular Cell · 2002 · 642 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Proteasome subunit Rpn1 binds ubiquitin-like protein domains

Suzanne Elsasser, Rayappa R. Gali, Martin Schwickart et al. · Nature Cell Biology · 2002 · 469 citations

Life Sciences, Biochemistry, Molecular Biology +14

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

Youzhi Li, Harry A. Rogoff, Sarah Keates et al. · Proceedings of the National Academy of Sciences · 2015 · 455 citations · Full text

Medicine, Cancer Biology, Oncology +17

The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

Alwin Köhler, Paolo Cascio, David Leggett et al. · Molecular Cell · 2001 · 415 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11