Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

Zhongyuan Liu, Xinqiang Yao, Wangsheng Jiang, +6

Journal of Neuroinflammation

Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs–NF–κB signaling pathway and pyroptosis after secondary spinal cord injury

Zhongyuan Liu, Xinqiang Yao, Baihui Sun, +6

Free Radical Biology and Medicine

InflammationAnti-inflammatoryMicroglia-mediate NeuroinflammationMedicineBrain-immune Interaction +8

Advanced oxidation protein products increase TNF-α and IL-1β expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression

Congrui Liao, Shengnan Wang, Siyuan Zhu, +6

Redox Biology

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products

Wei Li, Wangsheng Jiang, Yaru Su, +8

Cell Death and Disease

Advanced oxidation protein products induce pre‐osteoblast apoptosis through a nicotinamide adenine dinucleotide phosphate oxidase‐dependent, mitogen‐activated protein kinases‐mediated intrinsic apoptosis pathway

Siyuan Zhu, Jingshen Zhuang, Qian Wu, +5

Aging Cell

Advanced oxidation protein products induce chondrocyte apoptosis via receptor for advanced glycation end products-mediated, redox-dependent intrinsic apoptosis pathway

Qian Wu, Zhaoming Zhong, Siyuan Zhu, +10

APOPTOSIS

InflammationOxysterolBiochemistryAdvanced Glycation EndApoptosis +9

Advanced oxidation protein products induce apoptosis of human chondrocyte through reactive oxygen species‐mediated mitochondrial dysfunction and endoplasmic reticulum stress pathways

Wenbin Ye, Siyuan Zhu, Congrui Liao, +4

Fundamental and Clinical Pharmacology

Mitochondrial DysfunctionLipid PeroxidationImmunologyCell DeathCell Death Mechanisms +20

Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling

Zhongyuan Liu, Kewu Tu, Peiqian Zou, +7

International Immunopharmacology

InflammationAnti-inflammatorySpinal Cord InjuryMedicineImmunology +9

Advanced oxidation protein products sensitized the transient receptor potential vanilloid 1 via NADPH oxidase 1 and 4 to cause mechanical hyperalgesia

Ruoting Ding, Hui Jiang, Baihui Sun, +6

Redox Biology

Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response

Tian Sun, Qian Chen, Siyuan Zhu, +6

International Journal of Molecular Medicine

Nadph OxidaseImmunologyRedox BiologyInflammatory ArthritisOxidative Stress +17