Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

Aparna R. Parikh, Ignaty Leshchiner, Liudmila Elagina, +44

Nature Medicine

Gastrointestinal OncologyTumor HeterogeneityMedicineCancer DetectionGastrointestinal Cancers +9

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

Nicholas J. Haradhvala, Mark B. Leick, Katie Maurer, +24

Nature Medicine

Lymphoid NeoplasiaDistinct Cellular DynamicsCancer ImmunosurveillanceMedicineMalignant Blood Disorder +7

Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer

James T. Coates, Sheng Sun, Ignaty Leshchiner, +19

Cancer Discovery

AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer

Ashish Noronha, Nishanth Belugali Nataraj, Joo Sang Lee, +36

Cancer Discovery

Abnormal Expression of Collagen IV in Lens Activates Unfolded Protein Response Resulting in Cataract

Brian P. Danysh, Xiaoyang Bai, Douglas B. Gould, +2

Journal of Biological Chemistry

Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

Erin M. Parry, Ignaty Leshchiner, Romain Guièze, +51

Nature Medicine

Hematological MalignancyChronic Lymphocytic LeukemiaEvolutionary HistoryMixed-phenotype Acute LeukemiaGenetics +6

Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance

Aishath Naeem, Filippo Utro, Qing Wang, +21

Blood Advances

Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model

Brian P. Danysh, Erin Rieger, Deepankar Sinha, +4

Oncotarget

Braf V600e MutationOncologyBraf V600e InhibitorMedicineReceptor Tyrosine Kinase +11

Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer

Thomas C. Beadnell, Kelsey W. Nassar, Madison M. Rose, +5

Oncogenesis

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary <i>PIK3CA</i> Mutations

Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E. Martin, +27

Cancer Discovery