Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Michael Dudek, Dominik Pfister, Sainitin Donakonda, +45

Nature

Autoimmune DiseaseHepatologyImmune PathologyLiver PhysiologyT-regulatory Cell +10

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Sebastian Mueller, Thomas Engleitner, Roman Maresch, +46

Nature

Pancreatic CancerEvolutionary RoutesMedicinePathologyOncology +2

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

Tim Wartewig, Zsuzsanna Kurgyis, Selina J. Keppler, +9

Nature

ImmunologyT Cell LymphomagenesisAutoimmunityAdult T-cell Leukemia-lymphomaImmunotherapy +2

Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis

Yael Costa, R.M. Speed, Rupert Öllinger, +8

Journal of Cell Science

GeneticsMolecular BiologyCytoskeletonNovel ProteinsMicroarray Expression Profiling +15

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

Julia Weber, Rupert Öllinger, Mathias Friedrich, +28

Proceedings of the National Academy of Sciences

EngineeringGeneticsCrispr/cas9 Somatic Multiplex-mutagenesisTumor BiologyCrispr +14

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

Detian Yuan, Shan Huang, Emanuel Berger, +40

Cancer Cell

Chronic Mitochondrial DysfunctionMitochondrial FunctionBiliary CancerLiver PhysiologyImmunology +7

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

Roman Maresch, Sebastian Mueller, Christian Veltkamp, +26

Nature Communications

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

Felix Bayerl, Philippa Meiser, Sainitin Donakonda, +24

Immunity

RIG-I activation is critical for responsiveness to checkpoint blockade

Simon Heidegger, Alexander Wintges, Florian Stritzke, +17

Science Immunology

Mammalian Protein SCP1 Forms Synaptonemal Complex-like Structures in the Absence of Meiotic Chromosomes

Rupert Öllinger, Manfred Alsheimer, Ricardo Benavente

Molecular Biology of the Cell

GeneticsMolecular BiologyMolecular GeneticsCytoskeletonMeiosis-specific Proteins Scp1 +16