PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Masao Hashimoto, Koichi Araki, Maria A. Cardenas, +28

Nature

Autoimmune DiseaseT-regulatory CellImmunologyImmune RegulationPd-1 Combination Therapy +6

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J. Núñez, Flor Mendez, Padma Kadiyala, +32

Science Translational Medicine

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, +19

OncoImmunology

Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages

Zhihong Chen, James Ross, Dolores Hambardzumyan

Proceedings of the National Academy of Sciences

Oncologic ImagingImmunologyBiological MicroenvironmentsImmunoeditingInfiltrative Properties +16

Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma

James Ross, Zhihong Chen, Cameron J. Herting, +14

Brain

<scp>TRIM</scp>8 regulates stemness in glioblastoma through <scp>PIAS</scp>3‐<scp>STAT</scp>3

Changming Zhang, Carol Tucker‐Burden, James Ross, +3

Molecular Oncology

Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade

Hohyun Lee, Yutong Guo, James Ross, +3

Science Advances

A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression

Zhihong Chen, Bruno Giotti, Milota Kaluzová, +20

Journal of Clinical Investigation

Mdm InfiltrationImmunologyImmune RegulationTumor CellsParacrine Circuit +15

Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma

Zhihong Chen, Nishant Soni, Gonzalo Piñero, +16

Nature Communications

An early precursor CD8+ T cell that adapts to acute or chronic viral infection

Daniel T. McManus, Rajesh M. Valanparambil, Christopher B. Medina, +21

Nature