Concepedia

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J. Núñez, Flor Mendez, Padma Kadiyala, Mahmoud S. Alghamri, Masha G. Savelieff, María Belén Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda‐Alexandra Calinescu, Neha Kamran,

Science Translational Medicine · 2019 · 290 citations · 47 references

DOIFull text

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Abstract

glioma harboring TP53 and ATRX loss could improve the therapeutic efficacy of radiotherapy and, consequently, patient survival.

References

47

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 56.7K citations · Full text

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Nature · 2008 · 7.8K citations · Full text

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<i>IDH1</i>and<i>IDH2</i>Mutations in Gliomas

Hai Yan, D. Williams Parsons, Genglin Jin et al. · New England Journal of Medicine · 2009 · 5.9K citations · Full text

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

D. Williams Parsons, Siân Jones, Xiaosong Zhang et al. · Science · 2008 · 5.8K citations · Full text

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4.1K citations · Full text

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