Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB–IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial

Mary O’Brien, Luis Paz‐Ares, Sandrine Marréaud, +18

The Lancet Oncology

Interim AnalysisSurgical OncologyOncologyPembrolizumab Versus PlaceboImmunology +6

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males

Thomas Gerloff, Melanie Schaefer, Andreas Johne, +4

British Journal of Clinical Pharmacology

Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock

Juri Karjagin, Sandrine Lefeuvre, Kersti Oselin, +6

Clinical Pharmacology & Therapeutics

VP3-2022: Pembrolizumab (pembro) versus placebo for early-stage non-small cell lung cancer (NSCLC) following complete resection and adjuvant chemotherapy (chemo) when indicated: Randomized, triple-blind, phase III EORTC-1416-LCG/ETOP 8-15 – PEARLS/KEYNOTE-091 study

L. Paz-Ares, E O’Brien, M. Mauer, +17

Annals of Oncology

MedicineClinical TrialsAdjuvant ChemotherapyImmune Checkpoint InhibitorPharmacotherapy +7

MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes

Kersti Oselin, Thomas Gerloff, P.M. Mrozikiewicz, +2

Fundamental and Clinical Pharmacology

Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene

Kersti Oselin, Isabella Gashaw, P.M. Mrozikiewicz, +3

European Journal of Clinical Investigation

Short versus Long Infusion of Meropenem in Very-Low-Birth-Weight Neonates

Helgi Padari, Tuuli Metsvaht, Lenne‐Triin Körgvee, +7

Antimicrobial Agents and Chemotherapy

NeonatologyPharmacokinetic ModelingMeropenem ClearanceMedicinePediatrics +9

Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?

Helgi Padari, Kersti Oselin, Tõnis Tasa, +3

BMC Pediatrics

Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene

Kersti Oselin, P.M. Mrozikiewicz, Elena A. Gaikovitch, +2

European Journal of Clinical Pharmacology

MedicineGeneticsGenetic EpidemiologyHuman PolymorphismPathology +10

Quantitative determination of the human MRP1 and MRP2 mRNA expression in FACS‐sorted peripheral blood CD4⁺, CD8⁺, CD19⁺, and CD56⁺cells

Kersti Oselin, P.M. Mrozikiewicz, Rein Pähkla, +1

European Journal Of Haematology