Jan G. Felber

Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2

Yongfeng Tao, Jan G. Felber, Zhongyu Zou et al. · Angewandte Chemie International Edition · 2023 · 57 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

Jan G. Felber, Lukas Zeisel, Lena Poczka et al. · Journal of the American Chemical Society · 2021 · 54 citations

Life Sciences, Biochemistry, Molecular Biology +17

Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe

Lukas Zeisel, Jan G. Felber, Karoline Scholzen et al. · Chem · 2022 · 52 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

Jan G. Felber, Lena Poczka, Karoline Scholzen et al. · Nature Communications · 2022 · 44 citations · Full text

Life Sciences, Biochemistry, Chemical Biology +15

Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to <i>seco</i> -Duocarmycins Targeting the Thioredoxin System

Jan G. Felber, Annabel Kitowski, Lukas Zeisel et al. · ACS Central Science · 2023 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17