Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Ryan McCormack, Lesley R. de Armas, Motoaki Shiratsuchi, +15

eLife

InflammationProtein SecretionMicrobial PathogensIntracellular DefensePerforin-2 Knockout Mice +13

Cyclic and Acyclic Defensins Inhibit Human Immunodeficiency Virus Type-1 Replication by Different Mechanisms

Aprille Seidel, Ying Ye, Lesley R. de Armas, +6

PLoS ONE

Inhibition of Intracellular Bacterial Replication in Fibroblasts Is Dependent on the Perforin-Like Protein (Perforin-2) Encoded by Macrophage-Expressed Gene 1

Ryan McCormack, Lesley R. de Armas, Motoaki Shiratsuchi, +2

Journal of Innate Immunity

ImmunologyBacteriophageOuter Cell WallCytoskeletonCellular Physiology +16

Impact of aging and HIV infection on serologic response to seasonal influenza vaccination

Suresh Pallikkuth, Lesley R. de Armas, Stefano Rinaldi, +8

AIDS

Paradoxical aging in HIV: immune senescence of B Cells is most prominent in young age

Stefano Rinaldi, Suresh Pallikkuth, Varghese K. George, +12

Aging

Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages

Kenneth A. Fields, Ryan McCormack, Lesley R. de Armas, +1

Infection and Immunity

Medical MicrobiologyPathogenicityC Trachomatis L2Microbial DiseaseChlamydia Trachomatis +13

Reevaluation of immune activation in the era of cART and an aging HIV-infected population

Lesley R. de Armas, Suresh Pallikkuth, Varghese George, +3

JCI Insight

Immune ActivationHumoral ResponseImmunologyImmunodominanceCd4 T Cell Responses +17

Dysfunctional peripheral T follicular helper cells dominate in people with impaired influenza vaccine responses: Results from the FLORAH study

Suresh Pallikkuth, Lesley R. de Armas, Stefano Rinaldi, +4

PLoS Biology

VaccinationAg.ptfh CellsAdaptive Immune SystemHumoral ResponseImmunology +12

Impact of Early Antiretroviral Therapy Initiation on HIV-Specific CD4 and CD8 T Cell Function in Perinatally Infected Children

Stefano Rinaldi, Suresh Pallikkuth, Mark J. Cameron, +10

The Journal of Immunology

Induction of <i>IL21</i> in Peripheral T Follicular Helper Cells Is an Indicator of Influenza Vaccine Response in a Previously Vaccinated HIV-Infected Pediatric Cohort

Lesley R. de Armas, Nicola Cotugno, Suresh Pallikkuth, +8

The Journal of Immunology