Mindaugas Valius

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

Mindaugas Valius, Andrius Kazlauskas · Cell · 1993 · 655 citations

Signal Transduction, Molecular Physiology, Signaling Pathway +12

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

Andrius Kazlauskas, Adam Kashishian, Jonathan A. Cooper et al. · Molecular and Cellular Biology · 1992 · 228 citations · Full text

Immunology, Cellular Physiology, Signaling Pathway +21

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.

Andrius Kazlauskas, Gen‐Sheng Feng, Tony Pawson et al. · Proceedings of the National Academy of Sciences · 1993 · 212 citations · Full text

Molecular Biology, Cellular Physiology, Signaling Pathway +17

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

Mindaugas Valius, Chantal Bazenet, A. Kazlauskas · Molecular and Cellular Biology · 1993 · 208 citations · Full text

Pdgfr Mutants, Signal Transduction, Signaling Pathway +15

Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras Activity

Richard A. Klinghoffer, Brian Duckworth, Mindaugas Valius et al. · Molecular and Cellular Biology · 1996 · 131 citations · Full text

Immunology, Cellular Physiology, Signaling Pathway +19