CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Brian J. Lannutti, Sarah Meadows, Sarah E.M. Herman, +11

Blood

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

Wei Li, Riko Nishimura, Adam Kashishian, +4

Molecular and Cellular Biology

Molecular BiologyNew FunctionCell GrowthProtein Grb2Signaling Pathway +17

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

Adam Kashishian, Andrius Kazlauskas, Jonathan A. Cooper

The EMBO Journal

Pi3 KinaseSignal TransductionMolecular PhysiologySignaling PathwayNatural Sciences +12

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

Robert J. Lechleider, Satoru Sugimoto, Anton M. Bennett, +5

Journal of Biological Chemistry

p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes

David Chantry, Anne B. Vojtek, Adam Kashishian, +5

Journal of Biological Chemistry

Signal TransductionSignaling PathwayMedicineNatural SciencesReceptor Tyrosine Kinase +12

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

Andrius Kazlauskas, Adam Kashishian, Jonathan A. Cooper, +1

Molecular and Cellular Biology

ImmunologyCellular PhysiologySignaling PathwayReceptor Tyrosine KinaseAutophagy +19

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

Riko Nishimura, W Li, Adam Kashishian, +4

Molecular and Cellular Biology

Cellular PhysiologySignaling PathwayCell RegulationReceptor Tyrosine KinaseBinding Site +17

PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma

Sarah Meadows, Francisco Vega, Adam Kashishian, +5

Blood

DNA-Dependent Protein Kinase Is a Molecular Target for the Development of Noncytotoxic Radiation–Sensitizing Drugs

Eric T. Shinohara, Ling Geng, Jiahui Tan, +7

Cancer Research

EngineeringNoncytotoxic Radiation–sensitizing DrugsRadiation EffectRadiation ExposureMolecular Biology +17

AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region

Adam Kashishian, Monique Howard, Christine Loh, +3

Journal of Biological Chemistry