DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

Takuro Wada, Toshiyuki Takagi, Yuki Yamaguchi, +9

Genes & Development

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

Anton M. Bennett, Terry L. Tang, Satoru Sugimoto, +2

Proceedings of the National Academy of Sciences

Molecular PharmacologySignal TransductionMolecular PhysiologyDevelopmental BiologyG Protein-coupled Receptor +12

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

Robert J. Lechleider, Satoru Sugimoto, Anton M. Bennett, +5

Journal of Biological Chemistry

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

Satoru Sugimoto, Thomas J. Wandless, Steven E. Shoelson, +2

Journal of Biological Chemistry

Molecular BiologyInsulin SignalingSh2 DomainReceptor Tyrosine KinaseProteomics +15

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

Luiz Osório Leiria, Chih‐Hao Wang, Matthew D. Lynes, +24

Cell Metabolism

Glucose MetabolismBiochemistryLipid MetabolismPhysiologyBrown Fat +8

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

Farnaz Shamsi, Ruidan Xue, Tian Lian Huang, +23

Nature Communications

Metabolic RemodelingAdipokinesInsulin SignalingMetabolic SyndromeSignaling Pathway +18

Establishing a New Methodology for Genome Mining and Biosynthesis of Polyketides and Peptides through Yeast Molecular Genetics

Kan’ichiro Ishiuchi, Takehito Nakazawa, Takashi Ookuma, +8

ChemBioChem

Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase

Jaclyn M. Winter, Michio Sato, Satoru Sugimoto, +4

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringMolecular BiologyChemical BiologyBiosynthesis +14

Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation

Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, +19

Nature Metabolism

InflammationMetabolic SyndromeAnti-inflammatoryInflammatory DiseasePhysiology +10

Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2.

Satoru Sugimoto, Robert J. Lechleider, Steven E. Shoelson, +2

Journal of Biological Chemistry

Proteomic TechnologySrc Homology 2Signal TransductionProtein ExpressionBiochemistry +11