Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Marc Foretz, Sophie Hébrard, Jocelyne Leclerc, +6

Journal of Clinical Investigation

Lkb1/ampk PathwayInsulin SignalingMetabolic SyndromeHepatotoxicityMetabolic Signaling +23

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

Kei Sakamoto, Elham Zarrinpashneh, Grant R. Budas, +8

American Journal of Physiology-Endocrinology and Metabolism

Cardiac MuscleHeart FailureCardiovascular FunctionCardiac Lkb1Oxidative Stress +15

Crucial role for LKB1 to AMPKα2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes☆

Daphna D.J. Habets, Will A. Coumans, Mohammed El Hasnaoui, +7

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

CardiomyopathyMolecular PhysiologySignal TransductionMedicinePhysiology +8

Role of the α₂-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia

Elham Zarrinpashneh, Karla Carjaval, Christophe Beauloye, +10

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleCardiovascular FunctionCellular PhysiologyOxidative StressAmp-activated Protein Kinase +15

Dual cardiac contractile effects of the α₂-AMPK deletion in low-flow ischemia and reperfusion

Karla Carvajal, Elham Zarrinpashneh, Ondřej Szárszoi, +10

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleHeart FailureCreatine KinaseCardiovascular FunctionCellular Physiology +16

AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol

Elham Zarrinpashneh, Christophe Beauloye, Audrey Ginion, +6

Biochemical and Biophysical Research Communications

Cardiac MuscleCardiomyopathyMolecular PhysiologyCardiovascular DiseaseCardiac Physiology +10

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

Manabu Taneike, Kazuhiko Nishida, Shigemiki Omiya, +9

PLoS ONE

Cardiac MuscleMitophagyHeart FailureAutophagic FluxCell Death +18

Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents

Yu‐Chiang Lai, Elham Zarrinpashneh, Jørgen Jensen

Journal of Applied Physiology

Glycogen SynthaseMuscle FunctionBiochemistrySkeletal MuscleMedicine +13

Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction

Elham Zarrinpashneh, Tommaso Poggioli, Padmini Sarathchandra, +9

PLoS ONE

Cardiac RegenerationAngiogenesisStem CellsRadiation OncologyCell Signaling +16

Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart

Bénédicte Demeulder, Elham Zarrinpashneh, Audrey Ginion, +7

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cardiac MuscleSignal TransductionMolecular PhysiologyMedicinePhysiology +8