Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

Kristin N. Adams, Kevin K. Takaki, Lynn Connolly, +6

Cell

Medical MicrobiologyDrug ToleranceHealth SciencesMedicineImmunology +9

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

C.J. Cambier, Kevin K. Takaki, Ryan Larson, +5

Nature

Macrophage BiologyTuberculosisMembrane LipidsMicrobiologyHost-microbe Interaction +2

The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.

Paul N. Danese, William B. Snyder, Christine L. Cosma, +2

Genes & Development

Transcriptional RegulationDegp GeneProtein ExpressionMedicineNatural Sciences +10

Lethal paralysis of <i>Caenorhabditis elegans</i> by <i>Pseudomonas</i> <i>aeruginosa</i>

Creg Darby, Christine L. Cosma, James H. Thomas, +1

Proceedings of the National Academy of Sciences

Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway

William B. Snyder, Lenora J. Davis, Paul N. Danese, +2

Journal of Bacteriology

Proteinlipid InteractionMaltose SensitivityGeneticsLipid PeroxidationOxidative Stress +16

Superinfecting mycobacteria home to established tuberculous granulomas

Christine L. Cosma, Olivier Humbert, Lalita Ramakrishnan

Nature Immunology

Medical MicrobiologyPulmonary TuberculosisMicrobial DiseaseMycobacteria HomeTuberculosis +4

An In Vivo Platform for Rapid High-Throughput Antitubercular Drug Discovery

Kevin K. Takaki, Christine L. Cosma, Mark Troll, +1

Cell Reports

Drug TargetEngineeringVivo PlatformAntimicrobial ChemotherapyDrug Resistance +16

Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo

Steven Levitte, Kristin N. Adams, Russell D. Berg, +3

Cell Host & Microbe

Medical MicrobiologyPulmonary TuberculosisPathogenic MicrobiologyMicrobial DiseaseImmunology +7

<i>Mycobacterium marinum</i> Erp Is a Virulence Determinant Required for Cell Wall Integrity and Intracellular Survival

Christine L. Cosma, Kathryn A. Klein, Rosa Kim, +2

Infection and Immunity

Pathogenic MicrobiologyMicrobial PathogensBacteriologyVirulence Determinant RequiredBacterial Pathogens +18

Mutational activation of the Cpx signal transduction pathway of <i>Escherichia coli</i> suppresses the toxicity conferred by certain envelope‐associated stresses

Christine L. Cosma, Paul N. Danese, John H. Carlson, +2

Molecular Microbiology