Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice

Mathieu Darsigny, Jean‐Philippe Babeu, Andrée-Anne Dupuis, +6

PLoS ONE

Hepatocyte nuclear factor 4α contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation

Jean‐Philippe Babeu, Mathieu Darsigny, Carine Lussier, +1

American Journal of Physiology-Gastrointestinal and Liver Physiology

GastroenterologyPathologyHnf4alpha DeletionOrgan DevelopmentTranscriptional Regulation +14

Hepatocyte Nuclear Factor-4α Promotes Gut Neoplasia in Mice and Protects against the Production of Reactive Oxygen Species

Mathieu Darsigny, Jean‐Philippe Babeu, Ernest G. Seidman, +5

Cancer Research

Tissue DevelopmentHepatologyMedicineLiver PhysiologyCell Death +13

The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis

Morgane Placet, Guillaume Arguin, Caroline M. Molle, +7

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Tumor BiologyG Protein-coupled ReceptorMedicineApoptosisCell Death +7

Human Hepatocyte Nuclear Factor 4-α Encodes Isoforms with Distinct Transcriptional Functions

Élie Lambert, Jean‐Philippe Babeu, Joël Simoneau, +8

Molecular & Cellular Proteomics

Hepatocyte nuclear factor-4α promotes differentiation of intestinal epithelial cells in a coculture system

Carine Lussier, Jean‐Philippe Babeu, Benoît A. Auclair, +2

American Journal of Physiology-Gastrointestinal and Liver Physiology

Cell ProliferationCalbindin 3Organ DevelopmentCell SpecializationCoculture System +18

P1 promoter-driven HNF4α isoforms are specifically repressed by β-catenin signaling in colorectal cancer cells

Jean‐Philippe Babeu, Christine M. Jones, Sameh Geha, +2

Journal of Cell Science

PathologyCancer BiologyTumor BiologyTranscriptional RegulationSignaling Pathway +14

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells

Muhammad Sohail, Lulzim Shkreta, Johanne Toutant, +12

NAR Cancer

Loss of mesenchymal bone morphogenetic protein signaling leads to development of reactive stroma and initiation of the gastric neoplastic cascade

Sébastien A. B. Roy, Joannie M. Allaire, C Ouellet, +9

Scientific Reports

Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4α in Colorectal Cancer Cells

Jean‐Philippe Babeu, Samuel D. Wilson, Élie Lambert, +3

Cancers

PathologyCancer BiologyTumor BiologyProteomic TechnologyTranscriptional Regulation +15