Hiroshi Kotani

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

Hiromichi Ebi, Carlotta Costa, Anthony C. Faber et al. · Proceedings of the National Academy of Sciences · 2013 · 222 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in <i>KRAS</i> -Mutant Lung Cancer

Hidenori Kitai, Hiromichi Ebi, Shuta Tomida et al. · Cancer Discovery · 2016 · 163 citations · Full text

Life Sciences, Cell Biology, Oncology +17

4-1BB enhancement of CAR T function requires NF-κB and TRAFs

Gongbo Li, Justin C. Boucher, Hiroshi Kotani et al. · JCI Insight · 2018 · 148 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells

Emiliano Roselli, Justin C. Boucher, Gongbo Li et al. · Journal for ImmunoTherapy of Cancer · 2021 · 125 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis

Atsushi Masamune, Hiroshi Kotani, Franziska Lena Sörgel et al. · Gastroenterology · 2020 · 121 citations

Medicine, Molecular Biology, Pathology +12